Membrane proteins, including G protein coupled receptors, ion channels and transporters, play a key role in almost all physiological processes, including signal transduction, ion and small molecule transport and biological energy conversion. Abnormal function of membrane proteins can lead to cardiovascular disease, cancer, Alzheimer's disease, pain and other related diseases. At present, more than 50% of clinical drugs are designed with membrane proteins as targets.
Our structural biology experts can provide you with the most advanced structural biology technical services in the field of membrane proteins, including crystal structure, freeze electron microscope and NMR. On the one hand, we provide crystal structure services of membrane proteins that have been reported for the research and development of new drugs based on complex crystal structure or fragment; On the other hand, we also provide the structural analysis of membrane proteins, including the identification of the tertiary structure of antigen epitopes. If you are interested in our services, please feel free to contact us for more information.
One stop services include antigen preparation, antibody R & D, kit development, antibody detection to antibody production, antibody humanization, antibody affinity maturation, nano antibody and bispecific nano antibody production. If you are interested in our services, please feel free to contact us for more information.
Dock, discovery studio, Schrodinger and other software were used for protein structure modeling, molecular dynamics simulation, quantum chemical calculation and other molecular simulation calculations. About 100 compounds with high scores were selected, and then tested at the molecular and cellular levels in vitro. Finally, the affinity of 10 compounds was obtained μ M level.