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OUR PRODUCTS
OUR PRODUCTS
CrystalO Biopharma is committed to the research and development of membrane protein innovative drugs for major diseases such as Pain,parkinson’s disease and chronickidney disease and is determined to become a highly innovative and influential enterprise in the world.

G protein coupled receptor

G Protein-Coupled Receptors， GPCRs，It is a general term for a large class of membrane protein receptors. Crystal egg biology has rich experience in product R & D and production in the research field of G protein coupled receptor targets

Ion channel

Ion channel is the second largest drug target family and the target of many major diseases. Crystal egg biology has long been committed to the research and development of innovative drugs targeting ion channels, and has achieved great results. The following table shows our existing products. If you are interested in our products or services,

COVID-19

New Coronavirus pneumonia (COVID-19) has caused great damage to human life and health. To assist in the development of anti New Coronavirus drugs, the egg organisms have developed a series of coronavirus related products, including full-length N protein, S protein, M protein, E protein, 3CLpro, PLpro, ORF3a and ORF7a, etc.

Membrane protein assembled by nano disk

Soluble proteins are important Osmoregulation Substances and nutrients. Their increase and accumulation can improve the water holding capacity of cells and protect the vital substances and biofilm of cells. Therefore, they are often used as one of the indicators for screening resistance.
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OUR SERVICE
OUR SERVICE

Membrane proteins, including G protein coupled receptors, ion channels and transporters, play a key role in almost all physiological processes, including signal transduction, ion and small molecule transport and biological energy conversion. Abnormal function of membrane proteins can lead to cardiovascular disease, cancer, Alzheimer's disease, pain and other related diseases. At present, more than 50% of clinical drugs are designed with membrane proteins as targets.
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Our structural biology experts can provide you with the most advanced structural biology technical services in the field of membrane proteins, including crystal structure, freeze electron microscope and NMR. On the one hand, we provide crystal structure services of membrane proteins that have been reported for the research and development of new drugs based on complex crystal structure or fragment; On the other hand, we also provide the structural analysis of membrane proteins, including the identification of the tertiary structure of antigen epitopes. If you are interested in our services, please feel free to contact us for more information.
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One stop services include antigen preparation, antibody R & D, kit development, antibody detection to antibody production, antibody humanization, antibody affinity maturation, nano antibody and bispecific nano antibody production. If you are interested in our services, please feel free to contact us for more information.
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Dock, discovery studio, Schrodinger and other software were used for protein structure modeling, molecular dynamics simulation, quantum chemical calculation and other molecular simulation calculations. About 100 compounds with high scores were selected, and then tested at the molecular and cellular levels in vitro. Finally, the affinity of 10 compounds was obtained μ M level.
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  • Protein factory
  • Antibody production
  • Structural biology
  • Virtual machine Screening
    • ABOUT US
    ABOUT US
    CrystalO Biopharma was established in August 2019, adhering to the mission of "developing drugs with minimal side effects by precisely targeting ion channels, and bringing a better life through technology and innovation." We are committed to the research and development of drugs for Neurological andpsychiatric disorders, chronic kidney disease, and cardiovascular diseases. We aspire to become one of the most innovative and influential company globally. To date, we have successfully completed financing exceeding 100 million RMB.
    The core team of the company is composed of PhDs from top research institutes and pharmaceutical companies, such as Harvard University and the Shanghai Institute of Materia Medica.And we invited Erwin Neher, the Nobel Laureate in Physiology or Medicine and founder of the ion channel field, as the company's Chief Scientific Advisor. We are at the global forefront in the discovery of new ion channel targets, activity testing, and drug development based on structure and artificial intelligence.
    In 2020, we won “the first prize in the biomedical industry of the Shenzhen Innovation and Entrepreneurship Competition”, “the ‘Science and Innovation China’ Pioneer Technology Award in 2020”, “the National Excellence Award of the 9th China Innovation and Entrepreneurship Competition”, “the TOP10 of the Science and Innovation China Science and Technology Innovation and Entrepreneurship Competition”, “and the ‘Specialized, Fine, Special, and New’ SME award in Shenzhen”.
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    CORE TECHNOLOGIES
    CORE TECHNOLOGIES
    CrystalO Biopharma’s core technology platform has advanced instruments and equipment. The platform is furnished with a molecular cloning laboratory and a variety of protein expression and purification systems. We also possesse expertise in various techniques, including lipid cubic phase method and cryo-EM.
    NEWS AND PAPERS
    NEWS AND PAPERS

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